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We the Cells of the Body, Want to Create a More Perfect Union

Adam and Eve Choose Cabinet Members for the Body’s Society of Cells

Arielle Davidoff and Ashley Davidoff  Copyright 2017

 Look deep into nature and then you will understand everything better – Einstein 

As Adam and Eve entered the Garden of Eden they heard the cry of the disparate cells of the body:

“Without each other we are nothing.  Please unite us in structure and function with your wisdom. E Pluribus Unum!”

E Pluribus Unum – Out of Many, One

The cells knew they would be around for a long time; their grand scheme was to pursue Oneness. They understood the consequences of bullying, selfishness, greed, and jealousy. They also knew the power of goodness, integrity, humility, and sharing.  The cells resolved to fight the evil aspects of humanity.  56 cells from all walks of life discussed the issue of collaborative community living, and drafted a constitution they all signed in Philadelphia.  The cells submitted this proposal to Adam and Eve. It read:

We the Cells of the Body, in Order to form a more perfect Union, establish Justice, insure domestic Tranquility, provide for the common defence, promote the general Welfare, and secure the Blessings of Liberty to ourselves and our Posterity, do ordain and establish this Constitution for the United Cells of the Body.”

50 representative cells overlying the stars

Adam and Eve realized that the cell was the key “person” in their society 

Adam and Eve, taken aback by the wisdom of biology, accepted the proposal and recognized the document as a marvel of humanity.  They knew it was imperfect, but accepted that as humanity learned through time, experience, and application, it could be amended and better understood.

And so what to do now?

Adam and Eve’s first task was to choose leadership for this noble effort.  Which type of cells did the society of the body need? The stakes were high; they needed to organize an efficient society in which each of the body’s 37.2 trillion individual cells would be fed, protected, fulfilled and free.  In the Garden of Eden, Adam and Eve examined the variety of cells that surrounded them, then turned to consider the needs of society. thinking about which to choose.

Essential Functions

They debated and discussed how to build a body to house and protect its contents and enable the person to live a full and free life.  They spoke through the night and on the sixth day they arrived at a basic plan of a successful body’s most important functions. Those functions would fulfill the direction of the constitution they had drafted earlier.

Their plan was a simple list of the body’s essential functions:

  1. control, manage, direct
  2. protect and support
  3. provide food, energy, and manufacture needed products
  4. transport
  5. maintain
  6. produce and prepare the next generation

In the Garden of Eden, Adam and Eve entered the society of the cells and began to select societal leaders for the various essential functions on their list.

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Adam and Eve in the Garden of Eden’s Cell Shop

 Adam and Eve ventured into the Garden of Eden Cell Shop with their shopping list of the functional needs for their society.

Finding the Leader Cell to Control, Manage and Direct

The cell to govern the body would need an overview of the whole situation of life and Oneness.  Its chief characteristics would be wisdom, honesty, humility and integrity. It also needed to sense and react appropriately to both the external and internal environment so that everybody could live a safe and fulfilling life. This cell also had to be able to communicate with every cell in the body – all 37.2 trillion of them – from the tip of the head to the tips of the toes.

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The Neuron – “Il Presidente”

They chose the brain cell or neuron for its leadership, and they playfully called  it “Il Presidente.”  Crucially, the neuron could connect not only with other brain cells, but also (directly or indirectly) with every cell in the body. The neuron could also react to the outside environment.

Adam and Eve Trying on the Brain Cell for Size

 Adam tried on the brain cell and sought Eve’s approval.  It was tailored for both the internal and external environments.

Modified public domain work of Henri Rousseau “The Dream”  1910 (MoMA)

“Il presidente” made his first speech referencing Hillel’s sage advice: “If I am not for the body of my person who will be?  And if I am only for the body of my person, then what am I?  If not now when then?”

Adam and Eve nodded at each other, satisfied with their choice.

Finding a Cell for Protection  

Adam and Eve lived in a dangerous environment.  Wild, predatory animals ranged in size from the dinosaurs to violent religious zealots, to the smallest virus particles.  They identified two principal needs – protection from the outside, and protection from the inside of the body.  They turned first to secure internal security.

Adam and Eve were aware of Voltaire’s wise words: “Beware of the words ‘internal security,’ for they are the eternal cry of the oppressor.”  They also knew, conversely, that Cicero stated “Salus populi suprema lex esto”  –  “Let the good (or safety) of the people be the supreme (or highest) law.”

The cell responsible for internal environmental control had to be highly intelligent, so it could sensitively identify the enemy without racial profiling.  Adam and Eve searched for a long time before they encountered an amazing, introverted cell genius, decorated with Einstein’s hairstyle. They called it the macrophage.  This cell had an exquisite memory for detail and an uncanny ability to spot and destroy the enemy of peace.  Rebels and terrorists in the body were no match for this cell.

 

The Macrophage Police Cell with a Crazy Hairstyle

The macrophage’s motto was the simple equation:   E = mc2

Enemy of the Common Good will be taken down by the Macrophage with Great Conviction for the sake of the peace of humanity

Finding a Cell to Manufacture Food, Energy, and Other Needed Products

The manufacturing function related to internal economy.  Adam and Eve knew that a successful internal economy required self sufficiency. All able bodied cells had a right and an obligation to work.  Adam and Eve remembered and appreciated the wise words of the famous John Kennedy who declared “My fellow Americans, ask not what your country can do for you, ask what you can do for your country.”

The body would need manufacturing facilities present in all of its parts.  Noticing, however, that the liver cell proved especially adept at manufacturing, Adam and Eve chose this cell to lead the body’s internal economy.

The Liver Cell – Key in Metabolic Function in the Metabolic Warehouse of the Body

 

Finding a Cell to Lead the Transport Function

Transport to and from the cells would be an essential bodily function.  Adam and Eve chose the red cell to lead the effort, since it could transport oxygen and carbon dioxide, which they knew is vital to life.  The red cell with its colorful hemoglobin was a natural choice.  They recognized its ability to rapidly exchange gases in the lungs and at the cell as a stunning accomplishment of nature.

Red Cell with Hemoglobin Responsible for the Transport of Oxygen and Carbon Dioxide

Finding the Cell to Lead Maintenance: Repair, Cleaning and Waste Removal 

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Stem Cell Maintenance and Repair

The stem cell can magically transform into many different types of cells necessary to repair and regenerate tissues, which can wear over time. Timed cell death, or apoptosis, is natural and regeneration is necessary. The adult stem cell is responsible for regeneration of blood cells, endothelia of blood vessels, and epithelia of skin, intestine, and respiratory tract.  Adult stem cells also repair tissues such as bone, cartilage, and non-cardiac muscle, which are prone to injury due to physical activity.  Adam and Eve chose the multipotential adult stem cell to maintain the body’s cell populations.

Preparation for the Next Generation 

The miracle of creation understood the importance of education.  Each generation would advance to wholeness only if it learned from the experience of prior generations.  Humanity has preserved history in archives, museums, and libraries.  Similarly, within the nucleus of each cell lies the accumulated experience of the generations in the library of the DNA.  Every cell contains all this valuable information, which continues to evolve as human experience advances.

The Library of Accumulated Experience in the Nucleus of the Cell
Courtesy of photograph provided by Ralf Roletschek / fahrradmonteur.de subsequently modified 

Best for Last: Reproduction

Nature drives men and woman together with the most pleasurable and profound experience to enable e plurabus unum of the female egg and male sperm.  The mechanical union is infused with a miraculous spark of life that enables the continuation of the species.
Sperm and Egg Meet and a Miracle (not to be taken for granted) Occurs
Adam and Eve rested, exhausted in each other arms, assured that the wonderful human experiment had begun.

And the next day…

…there was a meeting of the minds on the palace lawn.

 7 Cabinet Ministers Posing in Front of Government Center

The 7 cells chosen by Adam and Eve to  to advise the design of the structure and function of the body.

From left to right; Liver cell (manufacture), Macrophage (defense and protection) Ovum (reproduction) Neuron (government) Sperm (reproduction) Stem cell (maintenance and repair) and Red cell (transport)

 

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Life, Cells, the US Constitution, and Trees

Life, Cells,the US Constitution, and Trees  

is an odd combination of concepts.  At first glance the title of the blog reveals a wide discrepancy of ideas, but in fact there are unifying concepts that bring them together.

The United States is one of the advanced cultures of the modern world. Its magnificent constitution states “We the People of the United States, in Order to form a more perfect Union, establish Justice, insure domestic Tranquility, provide for the common defence, promote the general Welfare, and secure the Blessings of Liberty to ourselves and our Posterity, do ordain and establish this Constitution for the United States of America.”   The wisdom rests firstly in the notion that “we the people” is the focus of all subsequent intentions resolutions and actions.  Secondly it provides hope and promise of a happy and safe society.  This statement of the constitution is satisfied in the biology of the cell, but not to the same extent in the dynamics of society.   We do not fully appreciate what perfection has been accomplished in the microcosm of our bodies nor how apt the opening statement is to the cells that make up living organisms. The cells in truth realise all the promises of the preamble, including a perfect union, justice, tranquility, defence, general welfare, liberty, and posterity.

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Trees, US Ideology, Cells, and the Body

Living structures are characterized by their ability to move, grow, reproduce, acquire and transport metabolic products, and protect themselves — all so they can function and contribute to the bigger community. The cell as the basic building block of life and living organisms performs all the described functions effortlessly, innately and automatically.  For the cell, life happens without struggle or effort.  People perform the same characteristics of life, but many individuals struggle to fulfil basic needs to satisfaction.

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Constitutional Makeup of the Body

The AiA art piece puts the cell in the centre of the body.  The cells, acting in combination with other cells, give life to their person in accordance with the preamble of the constitution. People in combination with other people give life to their society. 

From a physical perspective, biology has worked out a mechanism to keep all the 3.7 trillion cells of a single human being satisfied, fed, protected and fully functioning in their specific capacity. The liver cell is fulfilled in its capacity as a liver cell, and the same for the myocardial and brain cell.  In fact all animal cells live and do what they were born to do, and are fulfilled until disease or death. The world of botany has accomplished similar magnificence.cells-0005-catalogue-signed

Constitutional Makeup of the Tree

Tree cells in combination give life to the tree in accordance with the principles of the constitution.  

The 7.1 billion humans of the earth are still stuttering along, despite the lofty aspirations of the US Constitution.  Many citizens go hungry, innumerable are homeless and countless die in war.  The particular focus of this blog is to observe and appreciate the success of cells in the body, and try to understand and apply the processes that make them so successful to our society at large.

Branching Patterns in Nature – Success Story of Delivery and Waste Removal

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YinYang Tree – From Environment to Life in the Trees

The AiA rendering amplifies the arborising pattern of the roots and the branches in a background of the environment fuelled by the sun, air- filled atmosphere, and the earth.  The tree unit consists of two opposing forces just like the negative and positive forces of the atom.  The bare roots represent one force and the leaf filled flowering branches the other. They need each other and both need the environment (and the environment needs them) to develop, flourish and contribute.  They use a branching system at both ends to move nutrients and water efficiently .

What Do We as A Society Have to Learn from from the Yin-Yang Tree?

Opposing forces, when working together, enable both to flourish as individuals and as a new unit.  We need the man with the woman, the roots with the wings, the roots with the branches, the winter with the summer, the past with the future, the positive with the negative.  In the realm of tubes and flow we need a difference in pressure – a relative positive and a relative negative in order for the contents of the tube to flow.

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In the Leaves

The geometric arborising pattern is universal and is shown in veins of the ivy leaf 

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Heart Shaped Chines Lantern Flower

The dried flower reveals a delicate capillary-like infrastructure which is the transport mechanism for the petals. The flower enfolds and defends a barely appreciated, delicate fruit buried within its husk. The need to protect its fruit  manifests parental love which it can only do because it has an efficient transport mechanism to maintain itself.

 

Branching Patterns in the Body –The Vascular System

Supply and Removal of Metabolites and Waste

The transport systems of biology are exemplified by phenomenal branching tube morphology that is efficient.  The delivery and removal system in the form of arteries, capillaries and veins is 60,000 miles long (2.5 X the distance around the earth) – and with a pump that beats on the average of 72 times per minute,  3.7 trillion cells are continually fed and cleared of waste, and as a result can be  productive and fulfilled. Food is delivered and is waste removed from the front door of every cell constantly.  Each cell understands and applies the Goldilocks principle – “Take Not too much , nor too little, but what is just right for your needs.”

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The Pulsatile Miracle Circulation

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The Circulation; A Pump, Arteries, Capillaries, and Veins

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Capillary Network At the Front Door of the Cells

Specific Circulations

The Brain

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Arterial Tree of the Brain Under the Purple Moon

derivation, brain, artery, arteries, carotid artery, internal carotid artery, external carotid artery, trees, mountains, reflection, lake, mountains, normal, MRI, MRA, MR angiography, art, the common vein, art in anatomy, Ashley Davidoff MD

Derivation of the Arterial Tree of the Brain Under the Purple Moon

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Arterial Tree of the Brain – External and Internal Carotid Systems

The Heart

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The Crown-Like Coronary Arterial Tree

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Derivation of the Artistic rendering of the The Crown-Like Coronary Arterial Tree

The Lungs

heart, pulmonary circulation, pulmonary artery, capillaries, pulmonary veins, left atrium, intimacy, body language

The Pulmonary Circulation

The Gastrointestinal Tract

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Mesenteric Venous System of the Small Bowel

Note that the abdomen has been turned upside down in order to appreciate the tree like formation of the portal vein and small bowel.  

The liver is seen at bottom left in purple and the spleen (right) in orange

 The Spleenspleen, splenic artery, tree, trees of the body, arteriogram, radiology, art, the common vein, art in anatomy, Ashley Davidoff MD

The Splenic Arterial Tree

 

 The Kidneys

genitourinary system, genitourinary tract, kidney, arteries, veins, renal veins, renal arteries, normal, radiology, ultrasound, Doppler, power doppler, trees, branching, , Art in Anatomy, Ashley Davidoff MD.,

Renal Veins By Doppler Ultrasound in Spring

 The Liver

 

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The Hepatic Venules

 

Ductal Systems

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Ducts of the Breast

breasts, glands, ducts, histology, trees, trees in the body, mammary glands, art, the common vein, art in anatomy, Ashley Davidoff MD

Histology of the Glands of the Breast

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Bile Ductal System Working Night and Day

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Dilated Biliary Ductal System and the Bonsai Tree

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The Tree of the Prostate Gland

Organs and Other Structures with Tree Like Shapes

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A Forest of Kidney Trees

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Ginkgo Lung Tree

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A Winter Tree of Hands Under the Moonlight

The Brain

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The Brain Tree

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Derivation of the Brain Tree – Artistic Recreation 

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The Arbor Vitae – Tree of Life of the Cerebellum

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Tree -Like Purkinje Cells 

Drawing of Purkinje cells (A) and granule cells (B) from pigeon cerebellum by Santiago Ramón y Cajal, 1899; Instituto Cajal, Madrid, Spain. Public Domain

Drawing by Camillo Golgi of a hippocampus stained using the silver nitrate method and digitally rendered by the artist

This treelike branching pattern of neurons responsible for consciousness seems to be a structural feature of the universe itself.

Realising “We the People” – First Step – Efficient Supply and Removal of Metabolites and Waste for the People of the World

Without adequate food and water, the promise of “We the people” of the preamble of the constitution cannot be fulfilled. Currently 1 in 9 people in the world do not have enough food. Without this basic need they are unable to lead an active and healthy life.  Is it because there is not enough food in the world? Is it because the 3rd world starving countries are too far away from the excess food of the farms of abundance? The skin cell at the tip of the most remote toe or the most remote cell at the top of the head are equally supplied according to their need.  In a healthy individual no cell gets left behind.  Yet many people get left behind in the world.

How to do it?

To some extent we have built and continue to build an arborising network for water supply and waste removal.  In the US 86% of the population have clean water delivered.  In developing countries efficient water supply and sewerage facilities are lacking.  One in 10 people lack safe access to clean water, and 1 in 3 lack access to a toilet (water.org).  Building a similar network that spans the world and delivers food to the front door of all the people of the world is the obvious first step.  Yet it seems like a pipe dream.  The network of information provided by the internet was also a pipe dream for people like Nikola Tesla who had a vision for  a “world wireless system” in the early 1900s. The ability to deliver real time information to the front door via the world wide web is only 30 years old.  Could anybody prior to 20th century imagine such a technological accomplishment?  If only we could deliver food via an innate arborising pattern.  What if, for example, a high calorie liquid energy food could be delivered alongside the arborising water system?  It may not be a classical meal but it is certainly more than nothing. The practical intent of this blog  is to  draw parallels between biology and society, which can learn from an almost perfect delivery and removal system, most commonly in the form of tree-like branching.

The universe has evolved over about 13.7 billion years and  in so doing has the wisdom of time on its side.  Over this time, it has developed systems that optimise energy and efficiency.  We as thinking biological beings have evolved highly developed biological processes over the last 2.4 billion years.  We have developed a mind and free choice.  The mind for us has been a double edged sword – both a gift and a curse.  A gift because it has given us an ego, individuality, tribalism, heterogeneous cultures, poetry, literature, art, theater, science, dance, athletics, religion, and organization, but a curse that has brought ego, selfishness, pride, religion, jealousy, murder, bigotry, prejudice, and tribalism. The desire to live in “a more perfect Union, establish Justice, insure domestic Tranquility, provide for the common defence, promote the general Welfare, and secure the Blessings of Liberty to ourselves and our Posterity” requires that basic biological requirements are available and met.  The cells of the healthy body have acquired the aspirations of the US Constitution.

The cell has no mind nor ego and is therefore waiting only for evolutionary changes.  We as thinking beings want it all now, and continue to try and improve our lot in a lifetime and are too impatient to be happy with our lot.  We therefore push the double-edged envelope with our ego and in so doing while we are social beings we are competitive individuals at the same time.  This creates an internal conflict and conflict with others making perfect union a dream rather than reality.  The start for the world should be an efficient low energy, arborising delivery system, for food and water system for all people.  Without this the US Constitutional aspirations are only a dream.

Hillel recognized the conflict.  “If I am not for myself,” he said, “who will be for me?  And if I am only for myself, what am I.  And if not now when then?”  It is the balance of “I” and “they” that we have to find.  The cells have done it – Why can’t we?